People

Luke Jen O'Connor conducts applied mathematical research with a primary focus on statistical genetics. He has made contributions related to the genetic architecture of complex traits: their polygenicity, the influence of natural selection, and the contributions of rare and common variation. His recent interests also include genealogically informed algorithms and applications of artificial intelligence. 

Jay is a Ph.D. student in the Bioinformatics and Integrative Genomics (BIG) program. Originally from Seoul, South Korea, he earned his B.A. in Computational Biology from the University of Pennsylvania. He is broadly interested in how genetic variation in noncoding regions, such as untranslated regions, shapes gene regulation and contributes to human traits and disease.

Kangcheng Hou is a postdoctoral fellow co-mentored by Luke O'Connor and Alkes Price. His research currently focuses on leveraging functional information to characterize the role of common and rare genetic variants in complex traits.

Wenhan is a Senior Computational Associate at the Broad Institute. She earned her BS Degree in Mathematics at Nankai University and MS Degree in Biostatistics at Yale University. She is interested in developing statistical methods to reveal the functional and pleiotropic effect of rare coding variants using large-scale human genomic data.